| In the past decade, enormous advances have taken | | | | IFN-1 release occurs independently of this. |
| place in our understanding of the immune system, | | | | Antibody suppliers, like us at Novus Biologicals, |
| which has revolutionised immunotherapy treatment. | | | | provide a range of immunoglobulins targeted at |
| Focus has switched from fighting disease by studying | | | | proteins expressed in the SIV response. This is not |
| antibody reactions to known pathogens; today, there | | | | restricted to TLR-7 and 9. Other proteins, such as |
| is far more interest in natural immunity – that | | | | the co-receptor CXCR6, are also involved. |
| which has evolved naturally. | | | | Why are these products important in human |
| Traditionally, research was focussed on the B and T | | | | research? Well, SIV is closely related to human HIV. |
| cell response to specific pathogens - in other words, | | | | Therefore, study of SIV-infected primates |
| the development of antibodies through acquired | | | | contributes tremendously to the development of |
| immunity. This specific adaptive response to | | | | anti-HIV and AIDS treatments. The TLR family, |
| infectious diseases is well understood by most people. | | | | meanwhile, is used in numerous immunoassays |
| Where much current interest lies is in innate immunity. | | | | involving the cellular immune response. At least 10 |
| Innate immunity is generally non-specific. When the | | | | publications have cited TLR targeting as a tool in |
| body is targeted by a foreign body or other factor a | | | | cancer therapy. Studies using the TLR-7 antibody |
| broad-spectrum response is initiated, involving many | | | | resulted in the release of Imiquimod, a drug used in |
| proteins. Studying these proteins is of great benefit in | | | | the treatment of basal cell carcinomas. |
| studying non-infectious diseases such as cancer, and | | | | The Article is written by providing antibody catalogue |
| non-pathogen related inflammatory conditions such as | | | | and antibody database Services. Visit for more |
| psoriasis. | | | | information on Products & |
| To take one example, research into non-pathogenic | | | | ight information |
| versus pathogenic SIV (simian immunodeficiency | | | | This article is free for reproduction but must be |
| virus) shows release of interferon type l (IFN-1) in | | | | reproduced in its entirety, including live links & this |
| pathogenic cells. Initially, it was thought differences in | | | | copyright statement must be included. Visit for more |
| cell signalling between toll-like receptors (TLR) 7 and | | | | services! |
| TLR-9 was the cause. However, it is now thought | | | | |